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Targeted deletion of mouse Brainiac 1 results in preimplantation lethality. Blastocysts from Brainiac 1 heterozygote intercrosses isolated at 3.5 d.p.c. appear normal, with a clearly developed inner cell mass and an inner cavity. (A) Blastocyst genotyped as wild type. (B) Blastocyst genotyped as Brainiac 1 null.
