Table 3.
Clinical characteristics of TB/HIV co-infected children attending ART clinics of selected public hospitals in SNNPR, Ethiopia, from January 2009 to December 2019
| Clinical characteristics | Total | Censored | Dead | Log Rank test | ||
|---|---|---|---|---|---|---|
| X2 | P- value | |||||
| Baseline WHO stage | I & II | 60 (21.1) | 143 (96.6) | 5 (3.4) | 1.09 | 0.29 |
| III & IV | 224 (78.9) | 106 (77.9) | 30 (22.1) | |||
| ART eligibility criteria | CD4+ cells | 12 (4.2) | 12 (100) | 0 (0) | 14.35 | 0.001 |
| WHO stage | 117 (41.2) | 109 (93.2) | 8 (6.8) | |||
| Both | 78 (27.5) | 62 (79.5) | 16 (20.5) | |||
| Not recorded | 77 (27.1) | 66 (85.7) | 11 (14.3) | |||
| Baseline Opportunistic infection | Yes | 261 (91.9) | 229 (87.7) | 32 (12.3) | 0.44 | 0.50 |
| No | 23 (8.1) | 20 (87) | 3 (13) | |||
| Initial regimen | D4T based | 147 (51.8) | 129 (87.8) | 18 (12.2) | 0.66 | 0.88 |
| AZT based | 104 (36.6) | 90 (86.5) | 14 (13.5) | |||
| TDF based | 16 (5.6) | 15 (93.8) | 1 (6.2) | |||
| ABC based & 1j | 17 (6) | 15 (88.2) | 2 (11.8) | |||
| Initial regimen change | Yes | 135 (47.5) | 121 (89.6) | 14 (10.4) | 1.87 | 0.17 |
| No | 149 (52.5) | 128 (85.9) | 21 (14.1) | |||
| Reason for regimen change | Side effect | 33 (11.6) | 29 (87.9) | 4 (12.1) | 2.6 | 0.62 |
| Treatment failure | 24 (8.5) | 20 (83.3) | 4 (16.7) | |||
| TB | 30 (10.6) | 27 (90) | 3 (10) | |||
| Stock out | 35 (12.3) | 32 (91.4) | 3 (8.6) | |||
| Treatment failure | Yes | 40 (14.1) | 37 (92.5) | 3 (7.5) | 1.71 | 0.19 |
| No | 244 (85.9) | 212 (86.9) | 32 (13.5) | |||
| Baseline HIV related immune suppression | Mild/non-significant | 172 (60.6) | 164 (95.3) | 8 (4.7) | 33.24 | 0.001 |
| Advanced | 46 (16.2) | 40 (87) | 6 (13) | |||
| Severe | 66 (23.2) | 45 (68.2) | 21 (31.8) | |||
| INH | Yes | 182 (64.1) | 163 (89.6) | 19 (10.4) | 2.24 | 0.13 |
| No | 102 (35.9) | 86 (84.3) | 16 (15.7) | |||
| CPT | Yes | 260 (91.5) | 227 (87.3) | 33 (12.3) | 0.05 | 0.81 |
| No | 24 (8.5) | 22 (91.7) | 2 (8.3) | |||
| Baseline hemoglobin | ≤10 | 104 (36.6) | 89 (76.7) | 27 (23.3) | 21.05 | 0.001 |
| > 10 | 180 (63.4) | 249 (95.2) | 35 (12.3) | |||
| Adherence | Good | 266 (93.7) | 238 (89.5) | 28 (10.5) | 12.71 | 0.001 |
| Fair/poor | 18 (6.4) | 11 (61.1) | 7 (38.9) | |||
| Site of TB | Pulmonary | 218 (76.8) | 232 (90.3) | 25 (9.7) | 17.59 | 0.001 |
| Extrapulmonary | 66 (23.2) | 17 (63) | 10 (33) | |||
| Time of TB diagnosis | Pre ART | 171 (60.3) | 153 (89.5) | 18 (10.5) | 3.65 | 0.55 |
| ART | 113 (39.8) | 96 (85) | 17 (15) | |||
| Previous history of TB | Yes | 42 (14.8) | 29 (69) | 13 (31) | 19.85 | 0.001 |
| No | 242 (85.2) | 220 (90.9) | 22 (9.1) | |||
| TB drug resistance | No | 264 (93) | 237 (89.8) | 27 (10.2) | 20.29 | 0.001 |
| MDR | 20 (7) | 12 (60) | 8 (40) | |||