Table 5.
Cox-regression analysis of predictors of mortality of TB/HIV co-infected children attending ART clinics of public hospitals in SNNPR, Ethiopia from January 2009 to December 2019
| Variables | Categories | Death | Censored | CHR | AHR |
|---|---|---|---|---|---|
| Time of TB diagnosis | Pre ART | 18 | 153 | 0.52 (0.26-1.03) | 0.5 (0.18-1.36) |
| ART | 17 | 96 | 1 | 1 | |
| WHO stage at TB diagnosis | III | 14 | 169 | 1 | 1 |
| IV | 21 | 80 | 3.0 (1.53-5.95) | 1.61 (0.71-3.67) | |
| Hemoglobin level | ≤10 mg/dl | 27 | 89 | 5.23 (2.37-11.54) | 3.6 (1.39-9.31)* |
| > 10 mg/dl | 8 | 160 | 1 | 1 | |
| Site of TB | Pulmonary | 25 | 232 | 1 | 1 |
| Extrapulmonary | 10 | 17 | 4.2 (2.02-8.81) | 3.9 (1.34-11.45)* | |
| TB drug resistance | No | 27 | 237 | 1 | 1 |
| MDR | 8 | 12 | 5.1 (2.31-11.31) | 5.7 (2.07-15.96)* | |
| ART drug adherence | Good | 28 | 238 | 1 | 1 |
| Fair/Poor | 7 | 11 | 4.02 (1.75-9.22) | 2.9 (1.15-7.43)* | |
| Previous history of TB | Yes | 14 | 53 | 4.1 (2-8.33) | 2.63 (1.07-6.44) |
| No | 21 | 196 | 1 | 1 | |
| ART treatment failure | Yes | 3 | 37 | 0.46 (0.14-1.5) | 0.56 (0.16-1.93) |
| No | 212 | 32 | 1 | 1 | |
| IPT | Yes | 19 | 163 | 1 | 1 |
| No | 16 | 86 | 1.65 (0.85-3.22) | 0.55 (0.26-1.15) | |
| Baseline PTB | Yes | 20 | 159 | 0.55 (0.27-1.14) | 2.3 (0.66-8.17) |
| No | 15 | 90 | 1 | 1 | |
| Baseline EPTB | Yes | 4 | 13 | 2.3 (0.8-6.5) | 0.97 (0.24-3.9) |
| No | 31 | 236 | 1 | 1 | |
| Baseline oral thrush | Yes | 3 | 11 | 2.44 (0.74-8.01) | 3.7 (1.02-13.39) |
| No | 32 | 238 | 1 | 1 | |
| Baseline esophageal thrush | Yes | 2 | 6 | 3.3 (0.79-13.93) | 4.4 (0.77-25.02) |
| No | 33 | 243 | 1 | 1 |
CHR crude hazard ratio, AHR adjusted hazard ratio, *significantly associated variables with P < 0.05.