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. 2022 Jan 4;10:2. doi: 10.1186/s40478-021-01300-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Braak staging of neurofibrillary degeneration and Thal staging of β-amyloidosis. Examination of serial equidistant coronal sections stained with mAb Tau-1 detecting NFTs revealed that topographic expansion of neurofibrillary degeneration in subjects with DS results in progression from Braak stage I in 25- and 26-year-old subjects to stage VI in all subjects 51 years of age and older. The pattern of amyloid plaque distribution corresponds to Thal phase 5 in all subjects 28 years of age and older. Observed pattern reflects completion of topographic expansion at the beginning of fourth decade