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. 2022 Jan 4;10:2. doi: 10.1186/s40478-021-01300-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Rate of neuronal loss. The speed of neuronal loss is defined by the estimated rate of neuronal loss per day and the number of lost neurons per million neurons/day. Graphs a-c illustrate regional differences in the rate of neuronal loss in the fourth, fifth, and sixth decades of life, respectively, of DS subjects. b and d reveal the top level of the rate of neuronal loss in the fifth decade. The cumulative rate of neuronal loss (number of lost neurons per day in all examined regions) is similar in the fourth and fifth decades (4,318/day and 4,278/day, respectively) but decreases by half in the sixth decade (2,106/day) (e)