Table 1.

Clinical and neuropathological characteristics of DS subjects

#	Case #	Sex	Age (y)	Cause of death	Intellectual (IQ) deficit	Epilepsy	APOE allele	Dementia	Brain weight (g)	BraakStage: NFTs	Thal Phase: Aβ plaques
1	207–93	M	26					No signs	1,160	I	0
2	292–00	M	28	Gastrointest. hemorrhage				No signs	1,320	I	5
3	37–98	M	41		Severe, 28			Mild	1,130	II	5
4	M16-03	F	41	Peritonitis	Severe, 20			No signs	926	IV	5
5	256–00	F	43	Pneumonia	Profound, 17		3/4	No signs	990	V	5
6	257–00	M	48	Pneumonia	Profound, 12			No signs	940	IV	5
7	M9-04	M	48	Pneumonia	Severe, 27	+	4/4	Mild	920	VI	5
8	24–98	M	49		Mild, 50			Mild	1,100	III	5
9	1–98	M	51		Moderate, 41			Mod/ severe	840	VI	5
10	511–02	M	51	Pneumonia				Mod/ severe	954	VI	5
11	512–02	M	52	Cardiac infarct				Mod/ severe	1,194	VI	5
12	482–97	F	54	Pneumonia	Profound, 19	+	3/3		900	VI	5
13	181–00	M	54	Pneumonia	Moderate, 42			Mild	1,060	VI	5
14	55–03	M	54	Sepsis			3/3		774	VI	5
15	M18-03	F	56	SUDEP	Mild, 50	+		Mild	656	VI	5
16	M1-05	F	56	Asp. pneumonia	Moderate, 43	+		Severe	822	VI	5
17	M2-09	M	56	Asp. pneumonia	Mild, 58	+	3/3	Mod/ severe	762	VI	5
18	M2-06	M	56	Cardiac infarct			4/4		1,114	VI	5
19	M10-04	F	57	Pneumonia	Moderate, 42	+	3/3	Mod/ severe	960	VI	5
20	M3-05	F	57	Cardiac failure			3/4		696	VI	5
21	M1-06	M	57				3/3		1,000	VI	5
22	552–97	F	57		Profound, 15		3/3	Mod/ severe	790	VI	5
23	615–97	F	59	Cardiac failure	Profound, 18		4/3	Severe	740	VI	5
24	649–97	M	59		Profound, 5			Severe	1,060	VI	5
25	M11-04	M	59	Pneumonia	Moderate, 43		3/4	Severe	1,028	VI	5
26	M2-05	M	61	Pneumonia	Severe, 27			Severe	1,208	VI	5
27	M3-06	F	61	Subdural cerebellar hemorrhage			2/3	Severe	1,102	VI	5
28	37–99	M	63	Pneumonia	Severe, 20	+		Severe	700	VI	5
29	650–97	F	65		Severe, 26		4/4	Severe	830	VI	5
30	258–00	M	65	Pneumonia			3/3	Mod/ severe	900	VI	5
31	256–99	M	67					Severe	700	VI	5
32	M18-07	M	71	Multiple white matter infarcts	Severe, 26	+	3/3	Mod/ severe	960	VI	5
33	483–97	F	72						1,100	VI	5

M18-07 diagnosed with mosaic trisomy. SUDEP = sudden unexpected death in epilepsy