Table 10.
Brain region–specific amyloid volume (mm3) and amyloid load (%) in four DS age groups
| Structures/ subdivisions | DS 26–41 y | DS 43–49 y | DS 51–59 y | DS 61–72 y | ||||
|---|---|---|---|---|---|---|---|---|
| Volume | Load | Volume | Load | Volume | Load | Volume | Load | |
| Entorhinal cortex—all layers | 58.2 | 9.5 | 77.7 | 12.7 | 56.4 | 13.1 | 38.8 | 10.7 |
| CA1 | 1.3 | 0.4 | 10.3 | 4.0 | 18.4 | 9.0 | 10.4 | 7.0 |
| CA2 | 0.1 | 0.2 | 0.0 | 0.0 | 1.4 | 3.0 | 0.4 | 1.4 |
| CA3 | 0.1 | 0.2 | 0.4 | 1.3 | 1.6 | 5.0 | 0.7 | 2.0 |
| CA4 | 1.3 | 2.0 | 2.2 | 4.0 | 5.6 | 8.0 | 3.3 | 6.0 |
| Subiculum | 10.9 | 7.0 | 16.9 | 12.0 | 10.0 | 10.0 | 8.6 | 11.0 |
| Amygdala | 45.4 | 10.8 | 61.6 | 14.2 | 54.3 | 13.9 | 40.4 | 12.5 |
| Thalamus | 36.0 | 1.2 | 74.6 | 2.9 | 74.2 | 3.0 | 80.6 | 4.0 |
| Substantia nigra | 0.0 | 0.0 | 0.2 | 0.2 | 0.8 | 0.9 | 1.0 | 1.4 |
| MBC | 2.3 | 1.5 | 9.4 | 5.5 | 7.3 | 5.4 | 14.4 | 6.5 |
| Caudate nucleus | 81.8 | 3.6 | 189.9 | 11.2 | 140.0 | 9.5 | 222.7 | 15.0 |
| Cerebellar cortex molecular layer | 49.1 | 0.5 | 965.5 | 12.0 | 914.5 | 11.5 | 561.3 | 7.0 |
| Dentate nucleus | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Total (sum) Vol and mean load | 286.5 | 2.8 | 1,408.6 | 6.1 | 1,284.5 | 7.1 | 974.3 | 6.5 |