Table 3.
Estimated developmental volume deficit in DS cohort
| Structure/subdivision | Volume (mm3) in controls 25–43 y of age (N = 6) Mean and (SD) | Volume (mm3) in DS subjects 26–41 y (N = 4) Mean and (SD) | Volume deficit (mm3) difference between controls 25-43y of age and DS subjects 26–41 y of age | Volume deficit (%) | Volume deficit p < |
|---|---|---|---|---|---|
| Entorhinal cortex -all layers | 622.0 (85.6) | 612.7 (120.6) | 9.3 | 1.5 | ns |
| Entorhinal cortex—islands | 38.9 (6.4) | 32.2 (8.1) | 6.7 | 17.0 | ns |
| CA1 | 456.2 (49.6) | 332.2 (95.4) | 123.9 | 27.2 | ns |
| CA2 | 30.8 (4.4) | 42.8 (15.9) | – | – | – |
| CA3 | 44.7 (10.9) | 43.2 (20.9) | 1.4 | 3.2 | ns |
| CA4 | 102.7 (19.0) | 65.5 (21.8) | 37.2 | 36.2 | 0.042 |
| Subiculum | 184.2 (19.6) | 156.8 (34.4) | 27.5 | 14.9 | ns |
| Amygdala | 452.0 (65.1) | 420.5 (57.1) | 31.5 | 7.0 | ns |
| Thalamus | 3,639.7 (169.6) | 3002.7 (339.2) | 637.1 | 17.5 | ns |
| Substantia nigra | 110.0 (26.8) | 126.3 ( 12.2) | – | – | – |
| MBC | 123.3 (9.1) | 154.6 (19.3) | – | – | – |
| Caudate nucleus | 1,939.2 (197.4) | 2271.5 (285.5) | – | – | – |
| Cerebellum molecular layer | 14,348.0 (2,412) | 9813.0 (303.3) | 4,535.0 | 31.6 | ns |
| Dentate nucleus | 351.6 (62.4) | 270.0 (99.0) | 81.6 | 23.1 | ns |
| Cumulative developmental volume deficit: 5,491.2 mm3 | Mean developmental volume deficit: 12.8% |
MBC = magnocellular basal complex