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. 2022 Jan 4;19:3. doi: 10.1186/s12974-021-02367-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Increased IBA1 + cells are present in choroid plexus (CP) in Cx3cr1-iDTR and the iDTR mice after 3 day Dtx treatment. Genetic ablation of microglia in Cx3cr1-iDTR mice leads to ablation of IBA1 + microglia in the brain parenchyma (indicated in A and C by arrowheads). However, in the choroid plexus (CP) it leads to increased IBA1 + cells (indicated by arrows in B and D), suggesting a potential inflammatory response and possible infiltration of peripheral macrophages into CP. iDTR mice subjected to Dtx treatment does not result in microglia ablation (indicated in E by arrowheads) but likewise results in increased IBA1 + cells in CP, similar to Cx3cr1-iDTR mice (scale bar = 100 μm left column, scale bar = 20 μm right column). (n = 3–6 for each group, Mean ± SEM, **p < 0.01 and ***p < 0.001, one-way ANOVA). Quantification result is from one cohort of mice with similar results observed from > 2 other independent experiments