Table 1.
Characteristics of the included studies
| Reference | NOS | Country | Calendar period | Study type | Comparison population | Total no. of patients with IgG4-RD | Observed cancer cases | Expected cancer cases | Diagnostic criteria for IgG4-RD | Adjusted factors | Follow-up | Overall cancer SIR(95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Takahashi [6] | 6 | America | 1986–2008 | Registry-based | General America population | 111 | 3.00 | NA | HISORt criteria | Age, sex | 331 person-years | 16.0 (3.3–45.5) |
| Yamamoto et al. [8] | 5 | Japan | 1997–2011 | Registry-based | General Japan population | 106 | 6.00 | 2.87 | CDC | Age, sex | 3.1 years | 2.09 (0.77,4.55) |
| Shiokawa et al. [7] | 7 | Japan | 2001–2011 | Multicentre cohort | General Japan population | 108 | 18.00 | 6.70 | Asian diagnostic criteria [44], HISORt criteria | Age, sex, calendar year | 3.3 years/415.7 person-years | 2.70 (1.40,3.90) |
| Hirano et al. [3] | 6 | Japan | 1997–2012 | Multicentre cohort | General Japan population | 113 | 15.00 | NA | ICDC, CDC | Age, sex | 6.1 years | 1.04 (0.57,1.75) |
| Huggett et al. [9] | 5 | UK | 2004–2013 | Double-center cohort | General UK population | 115 | 9.00 | 4.50 | ICDC | Age, sex | 2.7 years | 2.00 (0.91,3.80) |
| Inoue et al. [10] | 5 | Japan | 2005–2013 | Registry-based | General Japan population | 235 | 15.00 | 12.90 | IgG4-RD Pathology Consensus Statement [45], ICDC | NA | 3.1 years | 1.16 (0.70,1.93) |
| Asano et al. [4] | 6 | Japan | 1992–2012 | Multicentre cohort | General Japan population | 158 | 34.00 | 16.9 | CDC, ICDC | Age, sex, calendar year | 6.0 years/940 person-years | 2.01 (1.34,2.69) |
| Sekiguchi et al. [12] | 4 | America | 1994–2012 | Registry-based |
General America population |
166 | 9.0 | NA | Modified CDC | NA | 2.4 years | 4.50 (1.50,7.50) |
| Ahn et al. [5] | 6 | Korea | 2006–2015 | Single-centre cohort |
General Korea population |
118 | 5.0 | 0.52 | CDC | NA | 0.7 years | 9.61 (3.12,22.40) |
| Tang et al. [13] | 6 | China | 2011–2018 | Single-centre cohort |
General China population |
587 | 10.0 | NA | CDC | Age, sex | 5.1 years | 2.78 (1.33,5.12) |
SIR standardized incidence ratio, CI confidence interval, NOS The Newcastle-Ottawa Scale, CDC Comprehensive Diagnostic Criteria for IgG4-RD [46], ICDC International Consensus Diagnostic Criteria for Autoimmune Pancreatitis [47], HISORt Criteria Diagnostic Criteria for Autoimmune Pancreatitis (Including Histology, Pancreatic imaging, Serology, Other organ involvement, Response to steroid therapy) [48], NA not available