Table 2.
Pathway analysis results (FDR correct P-values) using MetaboAnalyst showing the enriched metabolic pathways perturbed upon TiO2 NP exposure
| Metabolic pathway | PND 2–5 | PND 7–10 | PND 17–20 | |||
|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | |
| Alanine, aspartate, and glutamate metabolism | –1 | – | 8.06 × 10−3 | – | – | – |
| Aminoacyl-tRNA biosynthesis | 1.95 × 10−8 | 1.90 × 10−7 | 1.53 × 10−8 | 3.02 × 10−9 | 8.04 × 10−6 | 0.00184 |
| Arginine and proline metabolism | 0.00222 | 0.0342 | 5.33 × 10−3 | – | 0.0165 | 6.90 × 10−4 |
| Arginine biosynthesis | 0.0293 | 0.00599 | 4.19 × 10−4 | – | 1.14 × 10−4 | 1.00 × 10−4 |
| beta-Alanine metabolism | – | – | 0.0206 | – | – | – |
| d-Arginine and d-ornithine metabolism | 0.0293 | – | – | – | – | – |
| d-Glutamine and d-glutamate metabolism | 0.00344 | – | – | – | 0.0439 | – |
| Glutathione metabolism | 0.0293 | – | 0.0446 | – | – | – |
| Phenylalanine, tyrosine, and tryptophan biosynthesis | – | – | 0.0446 | – | – | – |
1FDR corrected P-value > 0.05 was marked by “–”,