Table 3.
Results (FDR correct P-values) of Metabolite Set Enrichment Analysis using MetaboAnalyst showing consistent changes among lipids
| Lipid subclass | PND 2–5 | PND 7–10 | PND 17–20 | |||
|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | |
| 1-Alkyl,2-acylglycerophosphocholines | 0.00119 | 2.02 × 10−37 | 1.82 × 10−15 | 6.29 × 10−9 | 0.0014 | 4.21 × 10−4 |
| Acylcarnitines | –1 | – | 0.00779 | 8.72 × 10−4 | – | – |
| Ceramide phosphocholines | – | – | 7.41 × 10−4 | – | 8.90 × 10−4 | – |
| Diacylglycerophosphocholines | 6.88 × 10−60 | 8.84 × 10−142 | 6.13 × 10−72 | 2.74 × 10−5 | 6.38 × 10−71 | 4.81 × 10−34 |
| Fatty acid esters | – | – | – | 0.0306 | – | – |
| Fatty acylcarnitines | 0.0445 | 0.00391 | 1.07 × 10−9 | 2.52 × 10−14 | – | 2.77 × 10−4 |
| Glycerophosphocholines | – | 1.59 × 10−4 | 0.00779 | – | 0.0495 | – |
| Glycerophospholipids | – | 3.92 × 10−5 | 0.00779 | 0.0460 | – | – |
| Lysophosphatidylcholines | 0.0420 | 5.75 × 10−5 | – | 0.0126 | 0.0373 | 0.0171 |
| Monoacylglycerophosphocholines | – | 0.0439 | 0.0162 | – | – | – |
| Phosphosphingolipids | 1.13 × 10−5 | 7.19 × 10−5 | 1.30 × 10−10 | – | 0.00354 | 0.00155 |
| Short-chain acylcarnitines | – | – | 6.11 × 10−8 | 1.30 × 10−9 | – | 2.87 × 10−9 |
1FDR corrected P-value > 0.05 was marked by “–”