Table 5.
Risk of VTE in patients with different T2DM durations
| Number of cases (%) | Number of controls (%) | Unadjusted ORs (95% CI) |
Adjusted ORs* (95% CI) |
|
|---|---|---|---|---|
| Last HbA1c: 0–5 y since T2DM diagnosis | ||||
| ≤ 6.5% (≤ 48 mmol/mol) | 446 (33.7) | 2042 (38.6) | 1.02 (0.86–1.20) | 1.06 (0.89–1.25) |
| > 6.5–7.0% (> 48–53 mmol/mol) | 210 (15.9) | 990 (18.7) | 1 (reference) | 1 (reference) |
| > 7.0–7.5% (> 53–58 mmol/mol) | 172 (13.0) | 651 (12.3) | 1.24 (1.01–1.51) | 1.20 (0.97–1.49) |
| > 7.5–8.0% (> 58–64 mmol/mol) | 86 (6.5) | 326 (6.2) | 1.30 (1.01–1.68) | 1.29 (1.00–1.67) |
| > 8.0–9.0% (> 64–75 mmol/mol) | 104 (7.9) | 336 (6.4) | 1.51 (1.20–1.91) | 1.44 (1.13–1.83) |
| > 9.0% (> 75 mmol/mol)) | 114 (8.6) | 348 (6.6) | 1.61 (1.27–2.03) | 1.39 (1.07–1.79) |
| No Recording | 191 (14.4) | 596 (11.3) | 1.75 (1.40–2.19) | 1.78 (1.41–2.24) |
| Last HbA1c: 5–10 y since T2DM diagnosis | ||||
| ≤ 6.5% (≤ 48 mmol/mol) | 260 (32.1) | 1168 (35.8) | 0.84 (0.69–1.02) | 0.83 (0.68–1.01) |
| > 6.5–7.0% (> 48–53 mmol/mol) | 161 (19.9) | 618 (19.0) | 1 (reference) | 1 (reference) |
| > 7.0–7.5% (> 53–58 mmol/mol) | 138 (17.1) | 525 (16.1) | 1.00 (0.80–1.27) | 0.97 (0.76–1.23) |
| > 7.5–8.0% (> 58–64 mmol/mol) | 58 (7.2) | 284 (8.7) | 0.78 (0.58–1.05) | 0.73 (0.53–1.01) |
| > 8.0–9.0% (> 64–75 mmol/mol) | 80 (9.9) | 270 (8.3) | 1.19 (0.90–1.57) | 1.11 (0.83–1.48) |
| > 9.0% (> 75 mmol/mol)) | 85 (10.5) | 306 (9.4) | 1.07 (0.81–1.40) | 0.87 (0.65–1.16) |
| No Recording | 27 (3.3) | 88 (2.7) | 1.24 (0.81–1.91) | 1.46 (0.93–2.31) |
| Last HbA1c: > 10 y since T2DM diagnosis | ||||
| ≤ 6.5% (≤ 48 mmol/mol) | 137 (26.3) | 599 (29.0) | 1.16 (0.87–1.55) | 1.10 (0.81–1.48) |
| > 6.5–7.0% (> 48–53 mmol/mol) | 70 (13.4) | 355 (17.2) | 1 (reference) | 1 (reference) |
| > 7.0–7.5% (> 53–58 mmol/mol) | 87 (16.7) | 346 (16.8) | 1.29 (0.95–1.76) | 1.20 (0.87–1.64) |
| > 7.5–8.0% (> 58–64 mmol/mol) | 64 (12.3) | 229 (11.1) | 1.42 (1.00–2.02) | 1.36 (0.94–1.96) |
| > 8.0–9.0% (> 64–75 mmol/mol) | 69 (13.2) | 228 (11.1) | 1.53 (1.10–2.14) | 1.40 (0.98–1.99) |
| > 9.0% (> 75 mmol/mol)) | 90 (17.3) | 275 (13.3) | 1.74 (1.26–2.40) | 1.33 (0.92–1.91) |
| No Recording | 4 (0.8) | 32 (1.6) | 0.56 (0.23–1.37) | 0.58 (0.22–1.52) |
*Adjusted for BMI (categorical), smoking (categorical), CHF, IHD, MI, stroke, hypertension, osteoarthritis, and use of insulin, bisphosphonate, systemic corticosteroids, low-dose acetylsalicylic acid, current and past use of metformin, and current and past use of sulfonylureas