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. 2022 Jan 5;21:12. doi: 10.1186/s12943-021-01480-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Hsa_circ_0003258 promotes PCa metastasis through the hsa_circ_0003258/ miR-653-5p/Arhgap5 pathway. A QRT-PCR assay explored the overexpression and knockdown efficiency of miR-653-5p. B The qRT-PCR showing the ARHGAP5 mRNA level of the predicated targets with miR-653-5p mimic or miR-653-5p inhibitor in PCa cells. C Western blot showing the protein levels of ARHGAP5 after overexpression or silencing of miR-653-5p. D-E Cell migration observed in transwell assay after overexpression or silencing of miR-653-5p. F-G Transwell assay and Western blot was performed after transfection with indicated vectors, lv- hsa_circ_0003258, mimic-nc or mimic-miR-653-5p. H-I Transwell assay and Western blot detected the migratory capacity and the protein level of PCa cells after silencing ARHGAP5. ns: Not Significant; * P < 0.05; ** P < 0.01; *** P < 0.001; ****P < 0.0001