Fig. 8.

Hsa_circ_0003258 promotes the metastasis of PCa cells in vivo. A-B The luciferase images and the gross observation of lung metastases in mice injected with DU145/sh-nc and DU145/sh-hsa_circ_0003258 cells (n = 5). C The number of metastatic nodules in lungs. D Kaplan–Meier overall survival curves of mice with PCa stratified by sh-hsa_circ_0003258 knockdown and negative control (log-rank test, n = 5, P = 0.0207). E The lung sections were stained with H&E. F Representative images of FISH analysis of hsa_circ_0003258 in lung tissues. G-H HDAC4 and ARHGAP5 expression in lung tissues detected by IHC. **** P < 0.0001