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. 2021 Dec 22;13:748198. doi: 10.3389/fnagi.2021.748198

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Copyright © 2021 Teipel, Dyrba, Vergallo, Lista, Habert, Potier, Lamari, Dubois, Hampel and Grothe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear spline estimates for CSF Aβ42 (Elecsys assay) vs. 18F-Florbetapir-PET SUVR in the ADNI sample, white matter reference. Spline regression with 95% confidence interval (dashed lines) of 18F-Florbetapir-PET SUVR_WM values on CSF Aβ42 levels using knots fixed at the first and the second tertiles of the range of 18F-Florbetapir-PET values. The 18F-Florbetapir-PET and CSF Aβ42 levels were scaled to a mean of 0 and a standard deviation of 1 to render models comparable across PVC methods and reference regions. Upper left: w/o (without) PVC, Upper right: PVC-2, Lower left: PVC-3.