Table 2.
Characteristics | N (%) | Model Comparing am to pm Clamping (for Midnight–Noon, n=1932; for Noon–Midnight, n=947) |
Model Comparing 6-h Time Periods of Clamping (for Midnight–6 am, n=1135; for 6 am–Noon, n=797; for Noon–6 pm, n=360; for 6 pm–Midnight, n=587) |
Model Using 6 pm–Midnight as Reference (for Midnight–6 pm, n=2292; for 6 pm–Midnight, n=587) |
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Adjusted Odds Ratio (95% Confidence Interval) | P Value | Adjusted Odds Ratio (95% Confidence Interval) | P Value | Adjusted Odds Ratio (95% Confidence Interval) | P Value | ||
Time of clamping | 0.03 | ||||||
Noon–midnight | 328 (35) | 1 (ref) | |||||
Midnight–noon | 526 (27) | 0.81 (0.67 to 0.98) | |||||
6 pm–midnight | 214 (36) | 1 (ref) | 0.15 | ||||
Midnight–6 am | 325 (29) | 0.77 (0.60 to 0.98) | |||||
6 am–noon | 201 (25) | 0.77 (0.59 to 1.00) | |||||
Noon–6 pm | 114 (32) | 0.85 (0.62 to 1.15) | |||||
6 pm–midnight | 214 (36) | 1 (ref) | 0.03 | ||||
Midnight–6 pm | 640 (28) | 0.78 (0.63 to 0.97) | |||||
Donor age, yr | 1.01 (1.00 to 1.02) | <0.001 | 1.01 (1.00 to 1.02) | <0.001 | 1.01 (1.00 to 1.02) | <0.001 | |
Terminal donor serum creatinine (per 0.01 mg/dl) | 1.01 (1.00 to 1.01) | <0.001 | 1.01 (1.00 to 1.01) | <0.001 | 1.01 (1.00 to 1.01) | <0.001 | |
Cause donor death | 0.19 | 0.2 | 0.21 | ||||
Other | 345 (28) | 1 (ref) | 1 (ref) | 1 (ref) | |||
CVA | 509 (31) | 1.14 (0.94 to 1.38) | 1.13 (0.93 to 1.38) | 1.13 (0.93 to 1.38) | |||
Donor CMV serology | 0.22 | 0.24 | 0.24 | ||||
Negative | 386 (32) | 1 (ref) | 1 (ref) | 1 (ref) | |||
Positive | 468 (28) | 0.89 (0.74 to 1.07) | 0.90 (0.75 to 1.08) | 0.90 (0.75 to 1.08) | |||
Sex | 0.001 | <0.001 | 0.002 | ||||
Female | 268 (26) | 1 (ref) | 1 (ref) | 1 (ref) | |||
Male | 586 (32) | 1.37 (1.13 to 1.65) | 1.35 (1.12 to 1.64) | 1.36 (1.12 to 1.64) | |||
Recipient BMI, kg/m2 | 1.07 (1.05 to 1.09) | <0.001 | 1.07 (1.05 to 1.10) | <0.001 | 1.07 (1.05 to 1.10) | <0.001 | |
History of diabetes | 0.3 | 0.3 | 0.30 | ||||
No | 644 (28) | 1 (ref) | 1 (ref) | 1 (ref) | |||
Yes | 210 (34) | 0.89 (0.71 to 1.11) | 0.89 (0.71 to 1.11) | 0.89 (0.71 to 1.11) | |||
History of vascular disease | 0.02 | 0.02 | 0.02 | ||||
No | 653 (28) | 1 (ref) | 1 (ref) | 1 (ref) | |||
Yes | 201 (40) | 1.32 (1.05 to 1.65) | 1.32 (1.05 to 1.65) | 1.31 (1.05 to 1.65) | |||
History of cardiac disease | 0.001 | 0.001 | 0.001 | ||||
No | 522 (26) | 1 (ref) | 1 (ref) | 1 (ref) | |||
Yes | 332 (39) | 1.39 (1.14 to 1.69) | 1.38 (1.14 to 1.69) | 1.39 (1.14 to 1.69) | |||
Recipient blood group | 0.03 | 0.02 | 0.07 | ||||
A | 330 (27) | 1 (ref) | 1 (ref) | 1 (ref) | |||
AB | 45 (34) | 1.29 (1.24 to 0.98) | 1.31 (0.84 to 1.99) | 1.31 (0.85 to 2.00) | |||
B | 97 (29) | 1.15 (0.85 to 1.54) | 1.16 (0.86 to 1.56) | 1.16 (0.86 to 1.56) | |||
O | 382 (32) | 1.33 (1.10 to 1.62) | 1.33 (1.09 to 1.62) | 1.33 (1.10 to 1.62) | |||
HLA-A/-B/-DR incompatibilities ≥4 | 0.04 | 0.04 | 0.02 | ||||
No | 403 (27) | 1 (ref) | 1 (ref) | 1 (ref) | |||
Yes | 451 (32) | 1.30 (1.02 to 1.66) | 1.30 (1.02 to 1.66) | 1.24 (1.04 to 1.48) | |||
Cold ischemia time, h | 1.05 (1.02 to 1.06) | <0.001 | 1.05 (1.03 to 1.06) | <0.001 | 1.05 (1.03 to 1.06) | <0.001 |
Total n=2879. ref, reference; CVA, cerebrovascular accident; CMV, cytomegalovirus; BMI, body mass index.