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. 2021 Dec 22;12:787176. doi: 10.3389/fgene.2021.787176

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Copyright © 2021 Zhao, Cho and Nicolls.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential microbial interaction networks in the Kostic cohort. A directed graph displaying differential microbial species between tumor and normal groups (hub microbes) in the Kostic cohort (shown in rectangles; green: depleted in tumor, red: enriched in tumor). Microbes predicted to interacting with the hub microbes were shown based on their differential level between tumor and normal groups (shown in circles; blue: depleted in tumor, orange: enriched in tumor). The connections among microbes were depicted in red (induction) or blue (repression) based on the associations of the hub microbes and their related microbes.