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. 2021 Sep;32(9):2331–2351. doi: 10.1681/ASN.2021010105

Figure 4.

Figure 4.

Circulating AGP proteins correlated to structural lesions in kidney biopsy specimens. (A) Correlation between baseline serum concentrations of six AGP proteins and structural lesions observed in kidney biopsy specimens obtained from 105 subjects in the T2D validation cohort. Biopsies were obtained, on average, 1 year later after baseline examination. (B) Correlation between transcript levels of genes encoding for AGP proteins in glomerular (n=66) and tubular (n=47) compartments, and structural lesions in kidney biopsy specimens obtained from the subjects in T2D validation cohort. Transcripts for five of the six AGP proteins were identified. (C) Correlation between expression of exemplar miRNAs in glomerular (n=40) and tubular (n=26) compartments and structural lesions in kidney biopsy specimens obtained from the subjects in T2D validation cohort. Spearman correlation coefficients (r) with statistically significant P values (<0.05) are shown in bold. FPW, podocyte foot process width (nm); PD, percentage of GBM surface with podocyte detachment (%); Podo, mean number of podocytes per glomerulus; Sv, glomerular filtration surface area density. *P<0.05, **P<0.01, ***P<0.0001.