Kaplan–Meier curves for the cumulative incidence of (A) the primary composite end points, (B) the kidney composite end point, (C) hospitalization for heart failure or cardiovascular death, and (D) all-cause death in patients with stage 4 CKD at baseline. Primary composite end point, sustained eGFR decline ≥50%, ESKD, or kidney or cardiovascular death; secondary kidney composite end point, sustained eGFR decline ≥50%, ESKD, or kidney death.