Table 1.

Association of predicted pathogenic COL4A3–COL4A5 variants resulting in position 1 Gly substitutions with hematuria in 100,000 Genomes Project database

Gene	Number of Variants Resulting in Position 1 Gly Substitutions in 100,000 Genomes Project, n	Number of Variants Resulting in Position 1 Gly Substitutions Excluded after Filtering, n (%)	Number of Individuals with a Predicted Pathogenic Position 1 Gly Substitution		Chi Square (with Yates correction)	Two-Tailed P Value
			In Total with Hematuria (n=2221)	In Total without Hematuria (n=37,200)
COL4A5	20	1 (5)	12	9	95.83	<0.001
COL4A3	87	14 (16)	21	85	37.54	<0.001
COL4A4	84	13 (15)	19	95	24.14	<0.001