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. 2021 Sep;32(9):2242–2254. doi: 10.1681/ASN.2020111546

Figure 1.

Figure 1.

kSPH express the SARS-CoV-2 receptors. (A) Relative gen e expression, shown as TPM of ACE2, TMPRSS2, and BSG in hKEpC, grown in a monolayer, and kSPH. (B) Immunostaining of fetal kidney (FK) and adult kidney (AK) and lung tissues for ACE2, TMPRSS2, and CD147. (C) Immunostaining of kSPH derived from the adult kidneys of a healthy donor (left panel), a patient with CKD (middle panel), and from fetal kidney (right panel) for ACE2, TMPRSS2, and CD147. (D) kSPH were subcutaneously injected into NOD-SCID mice and the grafts were analyzed after 14 days for the formation of kidney tubuloids. Shown is immunofluorescence staining for the proximal tubule marker lotus tetragonolobus lectin (LTL; green) and ACE2 (red). DAPI, 4′,6-diamidino-2-phenylindole. (Scale bar: B: 100μm, C: 20μm, D: 20μm).