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. 2022 Jan 4;12(5):2206–2223. doi: 10.1016/j.apsb.2021.12.021

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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(A) HIV envelope trimer model. Conserved sites of vulnerability were highlighted as CD4bs (yellow) ringed with N-glycans (orange). The interface-directed antibody (1C2) showed significantly higher HIV neutralization breadth (87%) than N-glycan-dependent CD4-binding site E70 (25% HIV neutralization breadth) when vaccinating against a panel of clinical isolates. (B) Morphology of HIV envelope native flexibly linked trimer coupled to liposomes by negative stain electronic microscope. Reprinted with permission from Ref. 155. Copyright © 2019 Cell press.