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. 2022 Jan 5;18(1):e1010220. doi: 10.1371/journal.ppat.1010220

Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

Janna Heide, Sophia Schulte, Matin Kohsar, Thomas Theo Brehm, Marissa Herrmann, Hendrik Karsten, Matthias Marget, Sven Peine, Alexandra M Johansson, Alessandro Sette, Marc Lütgehetmann, William W Kwok, John Sidney, Julian Schulze zur Wiesch
PMCID: PMC8730411  PMID: 34986197

In Table 6, the 4th column of HLA alleles, the allele for DQB1 is missing a number. The correct column heading is: DQA1*05:01/DQB1*03:01. Please see the correct Table 6 below.

Table 6. In vitro binding capacity of 14 SARS-CoV-2-specific peptides to 22 frequent HLA class II MHC molecules.

Binding capacities are expressed as IC50 nM values measured in classical in vitro binding assays based on inhibition of binding of a high affinity radiolabeled ligand to purified HLA molecules. High affinity binding is defined as IC50 < 1,000 nM and highlighted by bold font. For reasons of comprehensibility, values larger than 40,000 nM are indicated by a dash. The total number of alleles bound as well as the response frequency (RF) of the responding peptide is shown. Mem_P30 and Mem_P36, with the highest RFs, bound to 12 and 13 HLA molecules, respectively.

Peptide aa position Sequence Alleles bound RF DPB1*
02:01
DPA1*01:03
DPB1*04:01
DQA1*05:01
DQB1*02:01
DQA1*05:01
DQB1*03:01
DQA1*03:01
DQB1*03:02
DQA1*01:01
DQB1*05:01
DQA1*01:02
DQB1*06:02
Env_11 46–60 L V K P S F Y V Y S R V K N L 13 36.1 42 63 - 5766 - - 24387
Mem_30 146–160 R G H L R I A G H H L G R C D 12 72.2 569 445 - 15141 - 37659 -
Mem_34 166–180 K E I T V A T S R T L S Y Y K 13 41.7 1909 3337 13645 649 17391 - 1827
Mem_36 176–190 L S Y Y K L G A S Q R V A G D 13 66.7 13822 - 22448 48 - 15193 428
Ncl_11 51–65 S W F T A L T Q H G K E D L K 9 46.9 - 35760 30440 1304 19748 - 952
Ncl_17 81–95 D D Q I G Y Y R R A T R R I R 7 56.3 34655 - - 5067 - - -
Ncl_18 86–100 Y Y R R A T R R I R G G D G K 6 56.3 - - - 6720 - - -
Ncl_22 106–120 P R W Y F Y Y L G T G P E A G 5 34.4 10053 - 79 1278 414 2239 7882
Ncl_25 121–135 L P Y G A N K D G I I W V A T 2 37.5 13013 20045 11706 14585 3795 - 203
Ncl_26 126–140 N K D G I I W V A T E G A L N 9 50 4140 8348 422 4027 103 - 2643
Ncl_44 216–230 D A A L A L L L L D R L N Q L 7 43.8 1162 2779 2487 22499 860 8458 2499
Ncl_45 221–235 L L L L D R L N Q L E S K M S 9 43.8 285 701 3315 - 11904 23089 8081
Ncl_54 266–280 K A Y N V T Q A F G R R G P E 9 43.8 8438 6056 - 794 33174 - 2936
Ncl_70 346–360 F K D Q V I L L N K H I D A Y 13 53.1 287 794 30656 33658 9176 6010 8602

Reference

  • 1.Heide J, Schulte S, Kohsar M, Brehm TT, Herrmann M, Karsten H, et al. (2021) Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19. PLoS Pathog 17(9): e1009842. doi: 10.1371/journal.ppat.1009842 [DOI] [PMC free article] [PubMed] [Google Scholar]

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