Table 1. Peak velocity of wild type and homozygous vmat2 mutant (HOM) larvae untreated (naïve) treated with pramipexole or L-Dopa.
Genotype | Drug | Dose | Peak velocity (mm/s) | |||
---|---|---|---|---|---|---|
Mean | ± | SEM | N | |||
HOM | Naïve | 2.29 | ± | 0.11 | 53 | |
Pramipexole | 1μM | 2.47 | ± | 0.190 | 18 | |
10μM | 2.37 | ± | 0.240 | 23 | ||
100μM | 1.80 | ± | 0.170 | 24 | ||
L-Dopa | 1μM | 1.80 | ± | 0.160 | 13 | |
10μM | 2.03 | ± | 0.230 | 11 | ||
100μM | 2.20 | ± | 0.120 | 38 | ||
WT | Naïve | 1.22 | ± | 0.070 | 40 | |
Pramipexole | 1μM | 1.23 | ± | 0.090 | 37 | |
10μM | 1.07 | ± | 0.100 | 24 | ||
100μM | 1.11 | ± | 0.100 | 30 | ||
L-Dopa | 1μM | 1.22 | ± | 0.120 | 19 | |
10μM | 1.53 | ± | 0.150 | 14 | ||
100μM | 1.13 | ± | 0.080 | 28 |