Table 3.

Recommendations for data elements to be included in studies on novel SCS modes for patients with CRPS.

1. Patient-related and CRPS-related data 2. Age 3. Sex 4. BMI 5. CRPS diagnosis confirmed as per IASP Budapest criteria including details of the four domains: sensory, motor, vasomotor, sudomotor 6. Type of trauma that preceeded CRPS 7. Duration of CRPS 8. Analgesic usage 9. Ability to work and or participate in activities important for the patient

Data related to SCS implant and mode

● Stimulation frequency, amplitude or voltage, pulse width, pulse shape  ● Details of the implanted lead in the epidural space and electrode(s) stimulated in relation to vertebral levels

Domains to be assessed at baseline and at serial post-SCS implantation follow-up visits

● Pain-related: NRS, BPI, neuropathic pain score (e.g., DN4) ● Pain-related domains:   ● Functional status (e.g., SF-36, PSQ-3)   ● Psychological status (e.g., PCS, GAD-7, PHQ-9)   ● Physical status (e.g., LEFS)  ○ Analgesic usage  ○ Effect of SCS on CRPS-associated domains  ○ SCS stimulation mode preference  ○ Adverse effects or events related to SCS  ○ Ability to work and or participate in activities important for the patient

SCS = spinal cord stimulation; CRPS = complex regional pain syndrome; BMI = body mass index; IASP = International Association for the Study of Pain; NRS = numerical rating scale; BPI = Brief Pain Inventory; DN4 = Douleur Neuropathique (four questions); SF-36 = Short Form survey (36 items); PSQ-3 = Pain and Sleep Questionnaire (three questions); PCS = Pain Catastrophizing Scale; GAD-7 = Generalized Anxiety Questionnaire (seven questions); PHQ-9 = Patient Health Questionnaire for Depression (nine questions); LEFS = Lower Extremity Function Scale.