Table 1.
Comparison of Baseline Characteristics Between Unmatched SRS and Conservative Management Cohorts
| Total (n = 1117) | SRS (n = 727) | Conservative Management (n = 388) | P Value | |
|---|---|---|---|---|
| Age, mean yr (SD) | 58.8 (13.4) | 56.9 (13.7) | 62.6 (12.0) | <0.001 |
| Male, n (%) | 242/1095 (22.1) | 160/725 (22.1) | 82/288 (22.2) | 0.972 |
| Baseline KPS, median (IQR) | 95 (90-100) | 90 (90-100) | 100 (90-100) | 0.014 |
| Diameter, mean mm (SD) | 19.6 (9.2) | 20.0 (9.4) | 18.9 (8.8) | 0.061 |
| Volume, mean cm3 (SD) | 4.1 (4.9) | 4.3 (4.0) | 3.7 (6.0) | 0.055 |
| Laterality, n (%) | ||||
| Right | 517/1099 (47.0) | 330/711 (46.4) | 187/388 (48.2) | 0.107 |
| Left | 336/1099 (47.7) | 336/711 (47.3) | 188/388 (48.5) | |
| Midline | 58/1099 (5.3) | 45/711 (6.3) | 13/388 (3.4) | |
| Location, n (%) | <0.001 | |||
| Skull base | 438/1112 (39.4) | 335/724 (46.3) | 103/388 (26.6) | |
| Convexity | 641/1112 (57.6) | 374/724 (51.7) | 267/388 (68.8) | |
| Other | 33/1112 (3.0) | 15/724 (2.1) | 18/388 (4.6) | |
| Margin dose, mean Gy (SD) | –– | 13.0 (1.9) | –– | –– |
| Maximum dose, mean Gy (SD) | –– | 26.0 (5.1) | –– | –– |
| Isocenters, median (IQR) | –– | 9 (6–15) | –– | –– |
| Treatment volume, mean cm3 (SD) | –– | 5.4 (4.7) | –– | –– |
| Imaging follow-up, mean mo (median; SD) | 52.6 (42; 39.6) | 57.2 (48; 43.7) | 43.5 (36; 27.9) | <0.001 |
| Clinical follow-up, mean mo (median; SD) | 51.9 (42; 39.2) | 56.3 (45; 43.3) | 43.5 (36; 27.9) | <0.001 |
Abbreviations: IQR, interquartile range; SD, standard deviation; SRS, stereotactic radiosurgery.
Bold values are those with P < 0.05.