Table 5.

Binding parameters between ligands and target protein FGFR-2

Phytochemicals	Binding energy (Kcal/mol)	Inhibition constant (µM)	Number of hydrogen bond	Amino acids involved in hydrogen bonding
Andrographolide	− 7.42	3.62	1	ALA 567
Bassic acid	− 7.64	2.51	4	GLU 574, GLU 489, ASP 644, LYS 517
Chrysin	− 6.82	10.06	2	ALA 567, LEU 487
Curdione	− 7.27	4.69	1	LYS 517
Emodin	− 7.37	3.94	3	GLU 565, ALA 567, LEU 487
Eriodyctiol	− 6.72	11.96	3	GLU 565, ALA 567, GLU 574
Isorhamnetin	− 6.87	9.26	5	LEU 487, ALA 567, GLU 565, ASP 644, GLU 534
Nectandrin B	− 7.50	3.20	3	ASN 571, GLU 574, LYS 517
Nimbolide	− 8.17	1.03	3	ALA 567, ASN 631, GLU 565
Oleanolic acid	− 8.77	372.58 nM	1	GLU 489
Panaxadiol	− 9.02	244.6 nM	1	GLU 574
Panaxatriol	− 8.61	486.38 nM	1	GLU 574
Salvicine	− 7.86	1.73	2	GLU 574, ASN 571
Tetrandine	− 7.69	2.32	2	GLU 604, TYR 606
Theaflavin	− 6.90	8.71	5	ASP 644, GLU 534, ALA 567, ASN 571, GLU 489
Tylophorine	− 7.61	2.66	1	LYS 517
Ursolic acid	− 8.61	490.22 nM	3	ASP 644, LYS 517, GLU 574
Withaferin A	− 8.63	469.67 nM	3	GLU 565, ALA 567, LYS 517
Hecogenin	− 8.87	314.06 nM	1	ALA 567
Dovitinib (Standard drug)	− 6.72	11.80	1	ASN 571
Gefitinib (Standard drug)	− 7.84	1.80	1	ALA 567