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. 2021 Dec 29;2021:5177488. doi: 10.1155/2021/5177488

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Copyright © 2021 Yu Ye et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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circFAT1 silencing inhibits osteoblastic differentiation potential of PDLSCs. (a)–(c) Western blot and RT-qPCR showed that osteogenic markers (RUNX2, OSX, COL1A, and COL3A) were downregulated in the circFAT1 siRNA-treated PDLSCs (si-FAT1 group). (d, e) Silence of circFAT1 reduced the ALP activity of PDLSCs 7 days after osteogenic induction. ARS showed the mineralization of PDLSCs was decreased significantly in the si-FAT1 group after osteogenic induction for 14 days. (f) Immunofluorescence experiments confirmed the decreased expression of ALP in the si-FAT1 group. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.