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. 2021 Dec 29;2021:5177488. doi: 10.1155/2021/5177488

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Copyright © 2021 Yu Ye et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SMAD5 regulates the osteoblastic differentiation ability of PDLSCs. (a)–(c) Western blot and RT-qPCR showed that osteogenic markers (RUNX2, OSX, COL1A, and COL3A) were downregulated in the SMAD5 siRNA-treated PDLSCs (si-SMAD5 group). (d, e) Silence of SMAD5 reduced the ALP activity of PDLSCs 7 days after osteogenic induction. ARS showed the mineralization of PDLSCs was decreased significantly in the si-SMAD5 group after osteogenic induction for 14 days. (f) Immunofluorescence experiments confirmed the decreased expression of ALP in the si-SMAD5 group. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.