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. 2021 Dec 29;2021:5177488. doi: 10.1155/2021/5177488

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Copyright © 2021 Yu Ye et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Silence of circFAT1 inhibits the osteogenic differentiation ability of PDLSCs in vivo. (a) The skull defect model of SD rats was constructed. (b) 3D reconstruction image of the rat skull showed that bone regeneration in si-FAT1 group was inhibited. (c) H&E staining and Masson staining results both indicated that the new bone mass in the si-FAT1 group was significantly reduced. (Scale bar: 50 μm) (d) The bone volume fraction (BV/TV) was decreased in the si-FAT1 group. (e) Experimental mechanism diagram: circFAT1 may regulate PDLSC bone regeneration by targeting SMAD5 through acting as a sponge for miR-4781-3p. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.