Table 1.
Baseline clinical characteristics of patients with spontaneous ICH in original cohort.
| Clinical variables | Total (n = 431) | 3-month functional outcome | 1-month mortality | ||||
|---|---|---|---|---|---|---|---|
| Poor outcome (n = 327) | Good outcome (n = 104) | p value | Death (n = 80) | Survival (n = 351) | p value | ||
| Age (year) | 58.76 ± 12.92 | 59.09 ± 13.10 | 57.72 ± 12.34 | 0.557 | 58.88 ± 13.77 | 58.74 ± 12.74 | 0.981 |
| Male | 299 (69.4) | 227 (69.4) | 72 (69.2) | 0.971 | 53 (66.3) | 246 (70.1) | 0.502 |
| GCS | 13 (8,15) | 12 (7,14) | 15 (14,15) | <0.001 | 8 (6,11) | 13 (10,15) | <0.001 |
| Admission SBP (mmHg) | 167.72 ± 28.65 | 168.77 ± 29.76 | 164.42 ± 24.68 | 0.117 | 164.30 ± 31.79 | 168.50 ± 27.88 | 0.498 |
| Admission DBP (mmHg) | 98.10 ± 17.94 | 98.08 ± 18.46 | 98.16 ± 16.31 | 0.723 | 95.04 ± 19.41 | 98.79 ± 17.55 | 0.114 |
| Onset to CT (hours) | 6 (4,12) | 6 (4,10) | 7 (4,20) | 0.020 | 5 (4,9) | 6 (4,13) | 0.262 |
| History of hypertension | 245 (56.8) | 188 (57.5) | 57 (54.8) | 0.630 | 46 (57.5) | 199 (56.7) | 0.896 |
| History of diabetes mellitus | 31 (7.2) | 28 (8.6) | 3 (2.9) | 0.051 | 3 (3.8) | 28 (8.0) | 0.187 |
| Smoking | 143 (33.2) | 117 (35.8) | 26 (25.0) | 0.042 | 23 (28.7) | 120 (34.2) | 0.351 |
| Previous stroke | 22 (5.1) | 19 (5.8) | 3 (2.9) | 0.238 | 2 (2.5) | 20 (5.7) | 0.373 |
| Antiplatelet or anticoagulation | 20 (4.6) | 14 (4.3) | 6 (5.8) | 0.718 | 5 (6.3) | 15 (4.3) | 0.643 |
| Hematoma volume (mL) | 20.30 (7.81,35.78) | 25.16 (9.06,40.42) | 9.25 (2.64,21.70) | <0.001 | 28.69 (10.72,49.69) | 17.69 (7.05,32.94) | <0.001 |
| Hematoma location | |||||||
| Supratentorial | 358 (83.1) | 284 (86.9) | 74 (71.2) | <0.001 | 66 (82.5) | 292 (83.2) | 0.882 |
| Infratentorial | 73 (16.9) | 43 (13.1) | 30 (28.8) | 14 (17.5) | 59 (16.8) | ||
| Presence of IVH | 170 (39.4) | 147 (45.0) | 23 (22.1) | <0.001 | 57 (71.3) | 113 (32.2) | <0.001 |
| Presence of HE | 104 (24.1) | 90 (27.5) | 14 (13.5) | 0.004 | 25 (31.3) | 79 (22.5) | 0.099 |
| Treatment | |||||||
| Surgical intervention | 114 (26.5) | 107 (32.7) | 7 (6.7) | <0.001 | 30 (37.5) | 84 (23.9) | 0.013 |
| Conservative treatment | 317 (73.5) | 220 (67.3) | 97 (93.3) | 50 (62.5) | 267 (76.1) | ||
| PLT (10ˆ9/L) | 151 (115,199) | 151 (114,198) | 150 (120,205) | 0.824 | 143 (112,199) | 151 (116,201) | 0.374 |
| PT (s) | 11.4 (10.9,12.3) | 11.4 (10.9,12.3) | 11.6 (10.9,12.3) | 0.482 | 11.8 (10.9,13.0) | 11.4 (10.9,12.1) | 0.075 |
| APTT (s) | 26.5 (23.7,29.7) | 26.5 (23.7,29.4) | 26.6 (23.8,30.3) | 0.811 | 26.5 (23.5,30.1) | 26.6 (23.8,29.5) | 0.974 |
| INR | 0.99 (0.93-1.06) | 0.98 (0.93,1.05) | 1.00 (0.94,1.06) | 0.153 | 1.00 (0.93,1.10) | 0.98 (0.93,1.04) | 0.066 |
| NLR | 8.18 (4.81,13.20) | 8.77 (5.14,13.88) | 6.44 (4.25,10.49) | 0.001 | 12.53 (7.99,19.48) | 7.35 (4.32,11.98) | <0.001 |
| Fibrinogen | 2.76 (2.29,3.38) | 2.92 (2.37,3.54) | 2.44 (2.20,2.97) | <0.001 | 3.34 (2.87,4.47) | 2.65 (2.23,3.23) | <0.001 |
| F-NLR score | |||||||
| 0 | 164 (38.1) | 102 (31.2) | 62 (59.6) | <0.001 | 7 (8.8) | 157 (44.7) | <0.001 |
| 1 | 183 (42.5) | 149 (45.6) | 34 (32.7) | 40 (50.0) | 143 (40.7) | ||
| 2 | 84 (19.5) | 76 (23.2) | 8 (7.7) | 33 (41.3) | 51 (14.5) | ||
Data are expressed as n (%), mean ± SD, or median (25th, 75th quartile). Abbreviation: ICH, intracerebral hemorrhage; SD, standard deviation; GCS, Glasgow Coma Scale; SBP, systolic blood pressure; DBP, diastolic blood pressure; IVH, intraventricular hemorrhage; HE, hematoma expansion; PLT, platelet; PT, prothrombin time; APTT, activated partial thromboplastin time; INR, international normalized ratio; F, fibrinogen; NLR, neutrophil to lymphocyte ratio.