TABLE 3.

Effect of PAC1 on tumor formation in mice

Pathway and day	PAC1 suppression		PAC1 induction
	No. of tumors	% of mice with tumors	No. of tumors	% of mice with tumors
MEK(218D,222D)
0	0–20	80	0–1	30
3	0–10	67	1–20	100
7	0–3	10	1–20	100
10	0–7	50	2–10	100
Ras(12V,37G)
0	20–50	100	0	0
3	0–18	51	1–39	68
7	0–7	67	1–50	83
14	0–4	42	5–50	100
21	0–9	58	2–50	100