TABLE 3.
Comparative genomic hybridization analysis of tumor DNAsa
| Tumor type | No. of tumors | Chromosomal change(s) |
|---|---|---|
| TgT121p53+/− CP | 12 | dec11 |
| 1 | dec11 (A2-B4) | |
| 1 | dec11 (A1-B3) | |
| 2 | None | |
| TgT121p53+/+ CP | 1 | dec11 (A1-B4); dec18 (A2-E4) |
| 1 | dec11 (A1-B3); dec1 (A2-B2); dec8 (E3-H5); dec19 (B-D3) | |
| 4 | None | |
| TgT121p53−/− CP | 4 | None |
| TgTΔN TL | 1 | inc4; inc5; inc10; inc15 (D1-F3) |
| 1 | inc4 (A5-E2); inc5; inc10; inc15 (A2-F3) |
a
Chromosomal changes are indicated as “dec” for DNA copy number decreases and “inc” for increases, followed by the affected mouse chromosome numbers or subchromosomal regions. For TgT121p53+/− CP tumors, where indicated the signal intensity was consistent with the loss of a single copy of chromosome 11. TgTΔN mice develop thymic lymphoma as a result of expressing the SV40 T-antigen mutant dl1135, thus inactivating p53, in thymocytes. TL, thymic lymphoma.