Figure 11.

INSTIs can bind differently to PFV and HIV intasomes. (A and B) Compound 4f bound to the (A) HIV (pink) and (B) PFV (gray) intasome. (C) Overlay of compound 4f binding modes. (D and E) Compound 4c, containing a 6-pentanol substituent, bound to the (D) HIV (green) and (E) PFV (gray, PDB 5FRN) intasome. (F) Overlay of compound 4c binding modes. Compound 4d, containing a 6-hexanol substituent, is also shown in its binding mode to the HIV (light blue) intasome. In (A), (B), (D), and (E), intasome active sites are shown as surface views, with labeled residues. R231 is poorly ordered in the map and is, therefore, displayed as an Ala stub. The terminal adenine is removed for clarity.