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. 2021 Aug 25;15(1):109–119. doi: 10.1038/s41385-021-00445-z

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Fig. 1 — a Cellular distribution of integrins α4β1 and α4β7 among the major leukocyte lineages within the peripheral (spleen) and mucosal (colonic LP) compartments. Cells were pregated on live, CD45⁺ cells, followed by opt-SNE analysis. Cell populations including CD4⁺ (CD4⁺ T cells), CD8⁺ (CD8⁺ T cells), CD19⁺/IgA⁺/IgG⁺ (B cells), TCRγδ⁺ (γδ T cells), CD56⁺ (NK/NKT), or MHCII⁺/CD11c⁺/CD11b⁺ (myeloid) cells are highlighted. b Percentages of α4β1- and α4β7-expressing cells within the indicated cell lineages from colonic LPMC and splenocytes. Each data point represents a single mouse. All data are presented as mean ± S.D, from n > 6 mice in each dataset. Statistical significance determined using ANOVA, followed by Tukey’s multiple comparison test. c Distribution of integrin expressing subpopulations within the CD4⁺, CD8⁺, and B-cell lineages. T- and B-cell populations were divided into the indicated memory subpopulations and the expression of α4β7 and α4β1 integrins determined.