Table 1.
Expression data for Gα12 and Gα13 in tumor tissues and cell lines, obtained either from (i) published reports, or (ii) database analysis (GEPIA, http://gepia.cancerpku.cn/index.html), as indicated.
Solid tumor types | Gα12-mRNA tumor vs normal | Gα12-protein tumor vs normal | Gα13-mRNA tumor vs normal | Gα13-protein tumor vs normal |
---|---|---|---|---|
Breast invasive carcinoma |
No change Source: GEPIA |
High in metastatic tumors Source: Kelly et al. [17] |
High in metastatic tumor cells Source: Rasheed et al. [26] |
High in metastatic tumor cells Source: Rasheed et al. [26] |
Cervical carcinoma |
Low in tumors Source: GEPIA P < 0.05 |
No report |
No Change Source: GEPIA |
No report |
Cholangiocarcinoma |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
No report |
Esophageal carcinoma |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
No report |
Glioblastoma multiforme |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
No report |
Head and neck squamous cell carcinoma |
High in tumors Source: GEPIA p < 0.05 |
High in tumors and metastases Source: Liu et al. [23] |
No Change Source: GEPIA |
High in tumors and metastases Source: Rasheed et al. [28] |
Lower grade glioma |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
No report |
hepatocellular carcinoma |
No Change Source: GEPIA |
High in tumors and metastases Source: Yang et al. [24] |
No Change Source: GEPIA |
No report |
Ovarian serous cystadenocarcinoma |
Low in tumors Source: GEPIA p < 0.05 |
High in tumor cells |
No Change Source: GEPIA |
High in tumor cells Source: Cai and Xu [71] |
Pancreatic adenocarcinoma |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
No report |
Prostate adenocarcinoma |
No Change Source: GEPIA |
High in metastatic tumors Source: Kelly et al. [17] |
mRNA does not correlate to protein Source: Rasheed et al. [25] |
High in metastatic tumor cells Source: Rasheed et al. [25] |
Skin cutaneous melanoma |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
No report |
Stomach adenocarcinoma |
High in tumors Source: GEPIA p < 0.05 |
No report |
High in tumors Source: GEPIA p < 0.05 |
High in tumors and metastases Source: Zhang et al. [27] |
Thymoma |
High in tumors Source: GEPIA p < 0.05 |
No report |
No Change Source: GEPIA |
No report |
Uterine corpus endometrial carcinoma |
Low in tumors Source: GEPIA p < 0.05 |
No report |
No Change Source: GEPIA |
No report |
Values in italic reflect that the expression was higher in tumor cells/tissues compared to normal cells/tissues, while bold indicates reduced expression.