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. 2021 Aug 21;15(1):74–83. doi: 10.1038/s41385-021-00441-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — THP-1 cells expressing non-targeting control (shCtr) or PTPN2-specific (shPTPN2) shRNA were differentiated into macrophages and treated for 24 h (A + B) or the indicated time (C–E) with 20 ng/ml IL-6 and analyzed for a IL6RA and b GP130 mRNA levels, as well as c–e IL-6Rα and GP130 protein levels. * = p < 0.05, *** = p < 0.001 relative to the same condition in shCtr cells, ANOVA with Dunnett’s multiple comparisons test; representative results from one out of three independent experiments with n = 5 (A + B) or n = 3 (C–E) independent replicates.