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. 2021 Oct 30;41(2):191–203. doi: 10.1038/s41388-021-02077-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Outline of genome-wide CRISPR/Cas9 knockout library screening in CRC cells. B Gene Ontology (GO) enrichment analysis of significantly downregulated genes in HCT116 cells treated with AZD6244. The Benjamini & Hochberg (BH) method was used for multiple comparison. C Heatmap of RTK genes in CRC cells treated with MEKi compared with DMSO control in GEO datasets. D Heatmap of RTKs genes in CRC cells treated with AZD6244 for 7 days. E GSEA analysis of the transmembrane receptor protein tyrosine kinase signaling pathway gene set in CRC cells treated with or without MEKi; datasets were from (C) and (D). p value and adjusted p value were determined by permutation test and Benjamini & Hochberg (BH) method, respectively. NES normalized enrichment score.