Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 30;41(2):191–203. doi: 10.1038/s41388-021-02077-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — A BALB/c Nude mice were subcutaneously inoculated with 3 × 10⁶ HCT116 cells on day 0. Tumor-bearing mice (n = 5) were treated with vehicle, AZD6244, BI-2536, or the combination when the tumor volume achieved ≈100 mm³. B Tumor growth curves for mice treated with vehicle, AZD6244, BI-2536, or the combination. C Tumor volume of xenograft tumors on day 26. Data represented as mean ± SD (n = 10). D Representative image of mice and tumors with different treatments on day 26. (E) Weights of xenograft tumors on day 26. Data represented as mean ± SD (n = 10). F–H Representative immunohistochemical images of Ki67 and Tunel staining in tumors from each group. Scale bar, 400 μM. G Quantification of Ki67⁺ cells. Data represented as mean ± SD (n = 5). H Quantification of Tunel⁺ cells. Data represented as mean ± SD (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001, or ****p < 0.0001.