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. Author manuscript; available in PMC: 2022 Feb 9.
Published in final edited form as: Leukemia. 2021 Aug 9;36(1):100–110. doi: 10.1038/s41375-021-01378-z

Figure 2. KDSR is essential for leukemia cells.

Figure 2.

(A) Growth competition assay of MV4-11 and MOLM13 cells transduced with RFP-labeled negative control sgRNAs (sgLUC and sgREN; grey lines) and sgRNAs targeting KDSR (sgKDSR#1 and sgKDSR#2; blue lines). (B) Effect of ectopically expressed KDSR cDNA (GFP-labeled) on the cell numbers of sgKDSR (RFP-labeled) transduced MV4-11 and MOLM13 cells. (C) Growth competition assay of KDSR depletion in eight cancer cell models. (D,E) Cell cycle monitored by EdU and DAPI, and (F,G) cellular apoptosis detected by Annexin V in MV4-11 and MOLM13 cells. Data are represented as mean ± SD of triplicated experiments. *P < 0.01 using Student’s t-test.