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. Author manuscript; available in PMC: 2022 Feb 9.
Published in final edited form as: Leukemia. 2021 Aug 9;36(1):100–110. doi: 10.1038/s41375-021-01378-z

Figure 5. Targeting KDSR sensitizes the leukemia cells to ER stress inducer tunicamycin.

Figure 5.

(A) Effect of tunicamycin on cell viability of KDSR-dependent (MV4-11, MOLM13) and -independent (293T, SW620) cells. (B) Western blot of KDSR and UPR checkpoint proteins in MV4-11 and 293T cells treated with tunicamycin. (C) TEM of MV4-11 cells treated with tunicamycin. Red arrows indicate ER. (D) Effect of tunicamycin on cell viability of MV4-11 and MOLM13 cells transduced with sgKDSR#1. Data are represented as mean ± SD of triplicated experiments. *P < 0.01 using Student’s t-test.