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. Author manuscript; available in PMC: 2023 Jan 4.
Published in final edited form as: Cell Metab. 2021 Dec 15;34(1):158–170.e5. doi: 10.1016/j.cmet.2021.11.013

Figure 5. TOX4 regulates hepatic glucose metabolism independent of insulin receptor.

Figure 5.

(A-B) Body weight (A) and 4-hr-fasting glucose (B) in 14- to 15-week-old male IR or TOX4 f/f (n=10), LIRKO (n=10) and liver-specific IR/TOX4 DKO (LIRTDKO, n=6) mice.

(C) PTT in 12- to 13-week-old TOX4/IR f/f (n=6) and LTIRDKO (n=9) mice.

(D) GTT, and (E) AUC in 14-week-old male IR f/f (n=6), LIRKO (n=9), LIRTDKO (n=6).

(F) 4-hr-fasting insulin of mice in (D).

(G) Liver gene expression as determined by QPCR.

(H) WB of selected liver proteins involved in glucose metabolism.

* p<0.05, **p<0.01, *** p<0.001, **** p<0.0001 by one-way ANOVA analysis in A-B, E-F; 2-tailed Student’s t-test in C and 2-way ANOVA in G. ns: no significant difference. Data are presented as means ± SEM.