Table 3.
Test set‐based OPERA (95% CI) estimated odds ratios per covariate‐adjusted standard deviation from univariable and multivariable analyses of mBCRS, polygenic risk score, and age (n = 794).
| Univariable | Multivariable | ||||||
|---|---|---|---|---|---|---|---|
| mBCRS only | PRS only | Age only | mBCRS + PRS | mBCRS + age | PRS + age | All three combined | |
| mBCRS | 1.58 (1.38, 1.81) | – | – | 1.58 (1.37, 1.81) | 1.56 (1.36, 1.79) | – | 1.56 (1.35, 1.79) |
| Polygenic risk score | – | 1.58 (1.36, 1.83) | – | 1.57 (1.35, 1.84) | – | 1.61 (1.38, 1.87) | 1.60 (1.37, 1.87) |
| Age at blood draw a | – | – | 1.35 (1.16, 1.57) | – | 1.31 (1.12, 1.53) | 1.38 (1.19, 1.62) | 1.35 (1.15, 1.58) |
| Log likelihood (null = −545.0) | −520.1 | −525.8 | −537.4 | −502.4 | −514.1 | −517.1 | −495.5 |
| LR χ2 DF b | 1 | 1 | 1 | 2 | 2 | 2 | 3 |
| χ 2 | 49.9 | 38.5 | 15.3 | 85.3 | 61.8 | 55.9 | 99.0 |
Breast cancer risk factors include the following: age at blood draw, menopause status, body mass index, interaction term for BMI and menopause, physical activity, alcohol consumption, age at first birth (among parous), total number of births, age at menarche, menopause age (among postmenopausal), smoking pack‐years, previous number of breast biopsies, family history of breast cancer (number of affected sisters, youngest age of sister’s diagnosis), educational attainment, and durations of postmenopausal hormone use and breastfeeding.
Residuals adjusted for all breast cancer risk factors, except for age at blood draw.
LR χ2 DF, likelihood ratio χ2 statistic degrees of freedom.