Table 1.
LncRNAs implicated in SLE and RA.
| LncRNAs | Site | Expression | Signaling | References |
|---|---|---|---|---|
| SLE | ||||
| GAS5* | PBMC/Serum | DOWN | MAPK signaling pathway | (25) |
| NEAT1* | PBMC | UP | MAPK signaling pathway | (37) |
| TUG1* | PBMC | DOWN | Unknown | (36) |
| ENST00000604411.1 | PBMC | UP | X chromosome inactivation | (34) |
| ENST00000501122.2 | PBMC | UP | Unknown | (34) |
| TCONS_00483150 | PBMC | DOWN | Unknown | (35) |
| lnc5150 | PBMC/Serum | DOWN | MAPK signaling pathway | (25) |
| AC007278.2 | PBMC | UP | Unknown | (42) |
| MALAT-1 | PBMC | UP | SIRT1 signaling pathway | (43) |
| uc001ykl.1 | B cell | DOWN | Unknown | (66) |
| ENST00000448942 | B cell | DOWN | Unknown | (66) |
| YPEL4 | Serum | UP | FcγR pathway | (69) |
| linc0949 | PBMC | DOWN | Unknown | (31) |
| linc0597 | PBMC/Serum | DOWN | Unknown | (31) |
| lnc0640 | Serum | UP | MAPK signaling pathway | (68) |
| lnc7074 | Serum | DOWN | MAPK signaling pathway | (68) |
| linc-DC | Serum | UP | Unknown | (68) |
| RA | ||||
| HOTAIR | Chondrocytes | DOWN | NF-κB signaling | (91) |
| HOTAIR | PBMC/Serum exosomes | UP | Unknown | (89, 90) |
| GAS5* | PBMC/Serum/S-erum exosomes | UP | AMPK pathway | (89) |
| GAS5* | FLS | DOWN | SIRT1 signaling pathway | (94) |
| MIR22HG | PBMC | UP | Unknown | (95) |
| ENST00000619282 | PBMC | UP | Unknown | (95) |
| DSCR9 | PBMC | DOWN | Unknown | (95) |
| LINC01189 | PBMC | DOWN | Unknown | (95) |
| MAPKAPK5-AS1 | PBMC | DOWN | Unknown | (95) |
| HIX003209 | PBMC | UP | IκBα/NF-κB/HIX003209-miR-6089-TLR4 | (98) |
| lnc-AL928768.3 | STs | UP | Unknown | (102) |
| lnc-AC091493.1 | STs | UP | Unknown | (102) |
| FER1L4 | FLS/STs | DOWN | NF-κB signaling | (103, 104) |
| linc00152 | FLS | UP | NF-κB signaling | (106) |
| FOXD2-AS1 | Serum/STs | UP | miR-331-3p/PIAS3 pathway | (107) |
| LERFS | FLS | DOWN | Unknown | (108) |
| ZNF667-AS1 | FLS | DOWN | JAK/STAT signaling | (109) |
| XIST | FLS | DOWN | miR-126-3p/NF-κB signaling | (110) |
| PICSAR | FLS | UP | Unknown | (111) |
| MEG3 | Chondrocytes | UP | AKT/mTOR | (112) |
| lncRNA-H19 | FLS | UP | PIK3/NF-κB pathway | (114, 117) |
| ZFAS1 | FLS | UP | Unknown | (121) |
| ITSN1-2 | FLS | DOWN | NOD2/RIP2 | (122) |
| RP11-83J16.1 | FLS | UP | Unknown | (124) |
| NEAT1* | PBMC exosomes | UP | Unknown | (129) |
| LUST | Serum exosomes | UP | Unknown | (89) |
| anti-NOS2A | Serum exosomes | UP | Unknown | (89) |
| SNHG4 | Serum exosomes | UP | Unknown | (89) |
| HAR1B | Serum exosomes | UP | Unknown | (89) |
| TUG1* | Serum exosomes | UP | Unknown | (89) |
DOWN is downregulated, UP is upregulated. The lncRNAs marked with * are shared both SLE and RA.