FIG. 1.

Conserved domains of HERP and HES with distinct features. Mouse HERP1, HERP2, and HES1 were aligned by Clustal W and presented using BOXSHADE. Identical amino acids are in black, and conserved residues are in gray. The basic helix-loop-helix dimerization domains and Orange repression domains (11) are indicated. An arrowhead indicates the invariant amino acid residues in the basic domain of HERP1 and HERP2 (glycine) and HES1 (proline). Asterisks indicate the conserved carboxyl-terminal tetrapeptide motifs, which are also divergent between the HERP (YRPW/YQPW) and HES (WRPW) families. The WRPW sequence of HES recruits the TLE/Groucho corepressor.