Fig. 2.

Effects of GPS on swelling and pain in acute gouty arthritis induced by MSU. a Representative photographs of ankles 24 h after MSU injection. Black arrow indicates the injected place. b Time courses of the effects of colchicine and different doses of GPS on paw swelling. n = 6 mice per group. c Comparison of the instep swelling indexes at different points after MSU injection in each group. d, f Time course of the effects of colchicine and different doses of GPS on mechanical and thermal allodynia. e, g Normalized AUC of d, f. Values are expressed as means ± SD. ^###p < 0.001 vs. the control group; *p < 0.05 vs. the MSU + Veh group; **p < 0.01 vs. the MSU + Veh group. ***p < 0.001 vs. the MSU + Veh group. ns, not significantly different from MSU + Veh group; one-way or two-way ANOVA followed by Tukey’s post hoc test