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. 2021 Sep 29;76(1):178–187. doi: 10.1007/s11418-021-01571-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — GPS inhibited the activation of NLRP3 inflammasome in paw tissue of acute gouty arthritis. NLRP3 (a), ASC (b) and Caspase-1 (c) protein expressions were evaluated 24 h after MSU injection. n = 6 mice per group. Measurements of NLRP3/β-actin, ASC/β-actin, and Caspase-1/β-actin were quantified by Image J software. d–f The mRNA levels of NLRP3, ASC, and Caspase-1 in paw tissue were determined by qPCR. g The activity of Caspase-1 in paw tissues of MSU-induced acute gouty arthritis mice was determined by the Caspase-1 Activity Kit. Values are expressed as means ± SD. ^#p < 0.05 vs. the control group; ^##p < 0.01 vs. the control group; ^###p < 0.001 vs. the control group; *p < 0.05 vs. the MSU + Veh group; **p < 0.01 vs. the MSU + Veh group. ***p < 0.001 vs. the MSU + Veh group. ns, not significantly different from MSU + Veh group