Fig. 6.

Relationship between TRP channel expression and clinical parameters: A Heat map of mRNA expression of TRP channels (TRPV2, TRPV4, TRPV6, TRPC1, TRPC4, TRPC6, TRPM4 and TRPM7) between different clinical parameters (FIGO stage, grade, histology, molecular class, steroid receptor expression, myometrial invasion, LVI and recurrence) in primary EC biopsies. Results are shown as mean relative expression to the geometric mean of housekeeping genes HPRT, PGK, ACTB and GAPDH. N = 54 p.s. B–H Relative expression of TRP channels displaying significant associations with certain clinical parameters: stage (compared to IA) (B), grade (C), histology (compared to endometrioid) (D), molecular subclass (compared to p53 abnormal) (E), steroid receptor expression (F), myometrial invasion (G) and recurrence (H). Data are represented as mean ± SEM. *p < 0.05 **p < 0.01 using univariate linear regression with mRNA expression (ΔCT) as dependent variable and clinical parameters as independent variable. N = 54 p.s