Table 1.

Total energy of binding of RBD with the human ACE2 receptor.

	Wild-type	Omicron
van der Waal energy	−363.775 ± 20.446 kJ/mol	−335.186 ± 21.937 kJ/mol
Electrostatic energy	−1232.614 ± 64.543 kJ/mol	−3083.962 ± 89.676 kJ/mol
Polar solvation energy	617.810 ± 161.796 kJ/mol	803.804 ± 119.784 kJ/mol
SASA energy	−43.889 ± 3.469 kJ/mol	−42.889 ± 3.818 kJ/mol
Binding energy	−1022.467 ± 150.703 kJ/mol	−2658.233 ± 129.686 kJ/mol